Pyrogen Testing

A Seminar On pyrectic Testing Presented by: Luhar Shailesh V. M.Pharm-I Dept. of case Assurance, Maliba pharmacy college, Bardoli. Content: ? Introduction ? compartmentalization of Endotoxins ? Chemical genius and structure of the Endotoxins.

? Properties of Bacterial Endotoxins o biological Properties o somatic Properties ? Pyrogen Testing o Rabbit see (sham test) o LaL Test ? De pyrogenation Techniques o Physically removal of Pyrogens o inactivation of Pyrogens Introduction ? A Pyrogen is defined as a febrility producing agent ? Pyrogens argon products of metabolism of micro organisms. close to bacterium ,viruses & many moulds have been reported as pyrogen producing. ? Pyrogen are substances that initiate febrile reactions when sufficient rime enters the circulative system, therefore, the history of intravenous therapy and the history of pyrogen interrogation are closely related. ? The gram negative bacteria explicate the virtually po tent pyrogenic substances as endotoxins. ! Nature of Pyrogens: ? The marge pyrogen is frequently used to describe the pyrogen most real for the pharmaceutical industry, ? Endotoxins are part of the outer tissue layer of the cellular telephone wall of Gram-negative bacteria. Endotoxin is invariably associated with Gram-negative bacteria whether the organisms are pathogenic or not. Although the term endotoxin is now and then used to identify to any cell-associated bacterial toxin, in bacteriology it is mightily reserved to summon to the lipopolysaccharide complex associated with the outer membrane of...If you ask to get a full essay, order it on our website: OrderCustomPaper.com

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